Figure 3

Average pain score due to the intrathecal injection of Melissa Officinalis in acute (0 – 10 min) and chronic (15 – 60 min) phases of formalin-induced pain in different groups. Pain scores of formalin-induced nociceptive behavior in the rats treated with Melisa officinalis (0, 5, 10 and 20 mg/kg). Pain scores were measured at 0~10 min (acute phase) and 15~60 min (slow phase) after formalin injection. Each data point represents mean and SEM from 6~8 rats. *, ** and ***: different from the pain scores in the sham group (p < 0.05, p < 0.01 and P < 0.001), respectively.