Does Acupuncture Alter Pain-related Functional Connectivity of the Central Nervous System? A Systematic Review

Table 2 Reported brain areas in patients after long-term acupuncture intervention.

Study	BIT	Diagnosis	Areas activated/deactivated	Reported reduction of pain
Chen et al [25]	fMRI	KO	ACC, MPFC, PAG, Ventral striatum	Yes
Li et al [28]	fMRI	CLBP	ACC, DLPFC, MPFC, Precuneus	Yes
Napadow et al [29]	fMRI	CTS	PrCG, S1, S2	Not reported
Napadow et al [30]	fMRI	CTS	ACC, Amyg, Hyp, IC, MPFC, S1	Not reported
Harris et al [27]	PET	FM	ACC, Amyg, CAU, CC, DLPFC, PUT, tmpole	Yes

The bold font indicates activation to acupuncture; italic font indicates deactivation to acupuncture.
ACC = anterior cingulate; Amyg = amygdala; CAU = caudate; CC = cingulate cortex; DLPFC = dorsolateral prefrontal cortex; Hyp = hypothalamus; IC = insular cortex, MPFC = medial prefrontal cortex; PAG = periaqueductal grey; PrCG = precentral gyrus; PUT = putamen; S1 = primary somatosensory cortex; S2 = secondary somatosensory cortex; tmpole = temporal pole.

ISSN: 3059-4049