Figure 4

Attenuated late-phase neuropathic pain behaviors induced by spinal nerve ligation (SNL) in rats treated repetitively by using postligation with Scolopendra pharmacopuncture (SPP). SNL resulted in significant reductions in the hind-paw-withdrawal threshold and the latency to mechanical and thermal stimuli, respectively, compared to those prior to saline (SAL) or SPP was administered [⁺p < 0.05, ⁺⁺p < 0.001 vs. the presurgical value (postoperative Day 0)]. Repeated daily injections of SPP suppressed SNL-induced (A) mechanical allodynia and (B) thermal hyperalgesia at late times in neuropathic rats (*p < 0.05, * *p < 0.001 vs. SNL+SPP group (postoperative Day 3). The difference between the SNL+SPP and the SNL+SAL groups was statistically significant (^#p < 0.05, ^##p < 0.001 vs. SNL+SAL group). Arrows indicate SAL or SPP injection time points.